Study Of HbA1c As A Reliable Indicator For Metabolic Syndrome In Non Diabetic Patients

Abstract

With the metabolic syndrome and diabetes mellitus increase in the recent decade, the importance of early detection of insulin resistance is essential. However, a simple method is not currently available for precise measurements. Therefore the aim of this study was to elucidate the association of HbA_1c with metabolic syndrome as a constellation of cardiovascular risk factors.

The study population consisted of 45 subjects with metabolic syndrome and 45 free of metabolic syndrome (control group).Total cholesterol, triglycerides, glucose, HbA_1c, body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure were measured in both groups. HbA_1c levels are found much more in MS group than the control group, 8,7% and 6,2%, respectively. The sensitivity and specificity of HbA_1c is significantly higher in metabolic syndrome patients, 86,7% and 46,67%, respectively. Additionally, subjects with metabolic syndrome exhibited significantly higher blood glucose, triglyceride, systolic/diastolic blood pressure and cholesterol. Our results suggest that HbA_1c may be a marker for metabolic syndrome and may identify in a certain degree insulin resistance subjects.